Background:

GIPR (gastric inhibitory polypeptide receptor) is a 466 amino acid protein belonging to the G-protein coupled receptor 2 family. The activity of GIPR is mediated by G proteins, which activate adenylyl cyclase. Expressed as two isoforms produced by alternative splicing, GIPR is a multi-pass cell membrane protein that acts as a receptor for the glucose-dependent insulinotropic polypeptide (GIP). GIP is a major physiologic factor in the augmentation of the insulin response to oral glucose. GIP is a peptide hormone that is released postprandially from the small intestine and acts in concert with glucagon-like peptide (GLP)-1 to potentiate glucose-induced insulin secretion from the pancreatic beta-cell.

Specificity:

GIPR polyclonal antibody detects endogenous levels of GIPR protein.

Alternative names:

Gastric inhibitory polypeptide receptor; GIP-R

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human GIPR.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 45 kDa

Applications:

WB,IHC

Usage:

WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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