Background:

UDP-glucuronosyltransferase isoenzymes (UGTs) catalyze the glucuronidation of small lipophilic molecules, thereby regulating the bioactivity and metabolic fate of a wide range of endogenous compounds and xenobiotics. Glucuronidation increases the polarity of lipophilic molecules and facilitates their entry into aqueous compartments and, ultimately, their excretion. In essence, glucuronidation provides a protective function by terminating or attenuating the biological activity of its substrates. The UGT3A family of isoenzymes are expressed in liver and kidney, and to a lesser, in the gastrointestinal tract. UGT3A2 (UDP glycosyltransferase 3 family, polypeptide A2) is a 523 amino acid single-pass type I membrane protein that belongs to the UDP-glycosyltransferase family. It has been suggested that members of the UGT3A family may have an important role in the metabolism and elimination of ursodeoxycholic acid, a metabolic byproduct of intestinal bacteria.

Specificity:

UGT3A2 polyclonal antibody detects endogenous levels of UGT3A2 protein.

Alternative names:

UDP-glucuronosyltransferase 3A2, UDPGT 3A2; UGT3A2; PSEC0073; UNQ842/PRO1780

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human UGT3A2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 75 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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