Background:

Bex3, also known as p75NTR-associated cell death executor (NADE), nerve growth factor receptor-associated protein 1 or ovarian granulosa cell 13 kDa protein HGR74, is a member of the Bex family involved in zinc-triggered neuronal cell death. It can be found in prostate, testis, liver, ovarian granulosa cells and seminal vesicle tissue shuttling between the cytoplasm and the nucleus. Bex3 interacts with Smac (second mitochondria-derived activator of caspase) via its C-terminal and regulates apoptosis by the inhibition of Smac ubiquitination. Bex3 also interacts with itself and the NGFR p75 DEATH domain. Bex3 may play a significant role in the pathogenosis of neurogenetic diseases.

Specificity:

NGFRAP1 polyclonal antibody detects endogenous levels of NGFRAP1 protein.

Alternative names:

Protein BEX3; Brain-expressed X-linked protein 3; Nerve growth factor receptor-associated protein 1; Ovarian granulosa cell 13.0 kDa protein HGR74; p75NTR-associated cell death executor; NGFRAP1; BEX3, DXS6984E, NADE

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human NGFRAP1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 24 kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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