Background:

The hyaluronan-binding protein 2 (HABP2), also designated plasma hyaluronan-binding protein (PHBP) or factor VII-activating protease, belongs to the peptidase S1 family and contains three EGF-like domains, one kringle domain and one peptidase S1 domain. HABP2 is a heterodimer that contains a heavy chain of 50 kDa and a light chain of 27 kDa, which are linked by a disulfide bond. HABP2 is ubiquitously expressed and acts as a serine protease with fibrinogen and fibronectin being the major substrates. HABP2 has been shown to cleave the alpha-chain at multiple sites and the beta-chain between lysine53 and lysine54, but not the gamma-chain of fibrinogen. Overexpression of HABP2 has been shown to occur in lung adenocarcinomas and may be a useful biomarker for that type of cancer.

Specificity:

HABP2 polyclonal antibody detects endogenous levels of HABP2 protein.

Alternative names:

Hyaluronan-binding protein 2; Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein; HABP2; HGFAL; PHBP

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human HABP2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 27 kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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