Background:

TDRKH (tudor and KH domain-containing protein), also known as TDRD2 (tudor domain-containing protein 2), is a 561 amino acid protein that contains two KH domains and one tudor domain. TDRKH exists as two alternatively spliced isoforms and interacts with HIWI and HILI2. The gene that encodes TDRKH contains roughly 21,310 bases and maps to human chromosome 1q21. With roughly 3,000 genes that span about 260 million base pairs, chromosome 1 makes up approximately 8% of the human genome. There are also a large number of diseases associated with chromosome 1, notably, the rare aging disease Hutchinson-Gilford progeria which is associated with the LMNA gene that encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Specificity:

TDRKH polyclonal antibody detects endogenous levels of TDRKH protein.

Alternative names:

Tudor and KH domain-containing protein; Tudor domain-containing protein 2; TDRKH; TDRD2

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human TDRKH.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 72 kDa

Applications:

WB

Usage:

WB: 1:500~1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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