Background:

Melanotransferrin is a member of the transferrin family of iron-binding proteins, which also includes serum transferrin, lactoferrin, and ovotransferrin, and it is highly expressed on melanoma cells. Melanotransferrin, also designated p97, shares a high degree of homology with transferrin, but does not play a significant role in the uptake of iron. Melanotransferrin utilizes a member of the low-density lipoprotein receptor family for transendothelial transport, which is not as efficient as the transport of transferrin through the corresponding transferrin receptor. The gene encoding human melanotransferrin maps to chromosome 3q28-29, and is predominantly expressed as either a membrane bound protein or a secreted form of the protein. Melanotransferrin is expressed in brain, where it may be involved in Alzheimer’s disease. Melanotransferrin may also protect against membrane-lipid peroxidation, possess a metalloprotease activity, and possibly participate in intracellular adhesion. Further research will be necessary to fully elucidate the functions of this protein.

Specificity:

MFI2 polyclonal antibody detects endogenous levels of MFI2 protein.

Alternative names:

Melanotransferrin; Melanoma-associated antigen p97; CD228; MFI2; MAP97

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human MFI2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 110 kDa

Applications:

WB,IF

Usage:

WB 1:500 - 1:2000 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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