Background:

The Collagen Type IX protein (also known as Collagen α1 Type IX) is encoded by the COL9A1 gene which possesses two promoter regions and codes for both a long chain Collagen Type IX protein expressed in the cartilage, and a shorter Collagen Type IX protein expressed in the cornea and vitreous. Collagen Type IX forms a heterotrimer with Collagen α2 Type IX and Collagen α3 Type IX. When it is expressed in hyaline cartilage, Collagen Type IX posseses a large N-terminal globular domain (NC4). The COL9A1 gene is also expressed in the human inner ear, and disruption of this gene in mice results in hearing loss, indicating the role of Collagen Type IX in hearing. Mutations in the COL9A1 gene are associated with multiple epiphyseal dysplasia (MED), a chondrodysplasia, in humans. Collagen Type IX is often co-localized with Collagen Type II, and may play a role in the interaction of fibrils between Collagen Type II and Collagen Type IX.

Specificity:

COL9A1 polyclonal antibody detects endogenous levels of COL9A1 protein.

Alternative names:

Collagen alpha-1(IX) chain; COL9A1

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human COL9A1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 65 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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