Background:

SAP 30BP (SAP 30 binding protein), also known as HTRG, HTRP or HCNGP, is a 308 amino acid protein that belongs to the HCNGP family and is believed to function as a transcription regulator. Expressed in brain, liver, spleen, kidney, lung and heart, SAP 30BP localizes to the nucleus and is induced in fibroblasts by binding of HSV-1 (herpes simplex virus 1). In the nucleus, SAP 30BP interacts with SAP 30, a component of the histone deacetylase complex that also contains mSin3A, HDAC1, HDAC2, RbAp48, RbAp46 and SAP 18. Via this interaction, SAP 30BP is thought to play a role in the regulation of genes related to cell survival. In addition, SAP 30BP is capable of inducing cell death, suggesting that it functions in cellular corepression of transcription and inhibition of cell survival.

Specificity:

SAP30BP polyclonal antibody detects endogenous levels of SAP30BP protein.

Alternative names:

SAP30-binding protein; Transcriptional regulator protein HCNGP; SAP30BP; HCNGP; HTRG; HTRP

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human SAP30BP.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 50 kDa

Applications:

WB IHC IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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