Background:

Jade-1, also known as PHF17 (PHD finger protein 17), is an 842 amino acid protein that localizes to both the cytoplasm and the nucleus and contains two PHD-type zinc fingers. Expressed at high levels in kidney tissue and also present in heart, pancreas and liver, Jade-1 functions as a transcriptional coactivator that, via its PHD zinc fingers, promotes the TIP30-dependent acetylation of Histone H4. Additionally, Jade-1 is thought to promote apoptosis and is down-regulated in renal carcinoma cells, suggesting a possible role in tumor suppression. Three isoforms of Jade-1, two of which are designated JADE1L and JADE1S, are produced via alternative splicing events. The gene encoding Jade-1 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Specificity:

PHF17 polyclonal antibody detects endogenous levels of PHF17 protein.

Alternative names:

Protein Jade-1; Jade family PHD finger protein 1; PHD finger protein 17; JADE1; KIAA1807; PHF17

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human PHF17.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 108 kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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