Background:

OXA1L (oxidase (cytochrome c) assembly 1-like), also known as OXA1, is a 435 mitochondrial inner membrane protein belonging to the evolutionarily conserved Oxa1/Alb3/YidC protein family. Members of the Oxa1/Alb3/YidC protein family are involved in the biogenesis of membrane proteins in mitochondria, chloroplasts and bacteria. Existing as three isoforms produced by alternative splicing events, OXA1L is required for the insertion of integral membrane proteins into the mitochondrial inner membrane. OXA1L is essential for the activity and assembly of cytochrome oxidase and for the correct biogenesis of F(1)F(o)-ATP synthase and NADH:ubiquinone oxidoreductase. Mutations in the gene encoding OXA1L might be involved in the pathology of combined enzymatic deficiencies of the oxidative phosphorylation (OXPHOS) system.

Specificity:

OXA1L polyclonal antibody detects endogenous levels of OXA1L protein.

Alternative names:

Mitochondrial inner membrane protein OXA1L; Has; OXA1Hs; Oxidase assembly 1-like protein; OXA1-like protein; OXA1L

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human OXA1L.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 42 kDa

Applications:

WB IHC IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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