Background:

Enhancer of Polycomb 1 (EPC1) is a member of the Polycomb group (PcG) proteins. EPC1 interacts with the transcriptional repressor E2F6. In proliferating cells, the proliferation-specific PcG, EZH2, associates with this E2F6-EPC1 complex, which may regulate genes required for cell cycle promotion. EPC1 also interacts with a member of the RING finger protein family (RFP), and this complex functions as a transcriptional repressor. Lastly, EPC1 is a com-ponent of the NuA4 histone acetyltransferase (HAT) complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. This acetylation may alter nucleosome-DNA interactions and promote interaction of the modified histones with other positive transcription regulators. The HAT complex may play a role in oncogene/proto-oncogene growth induction, tumor suppressor growth arrest, replicative senescence, apoptosis and DNA repair.

Specificity:

EPC1 polyclonal antibody detects endogenous levels of EPC1 protein.

Alternative names:

Enhancer of polycomb 1; Enhancer of polycomb homolog 1; EPC1; EPC1_HUMAN; Epl 1; Epl1;

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human EPC1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 105 kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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