Background:

CD155, a member of the immunoglobulin superfamily, acts as the human receptor for poliovirus (PV). All three serotypes of PV- PV1, 2, and 3- exhibit similar binding to CD155 in both its glycosylated and fully deglycosylated forms, indicating they utilize a common mechanism for cell entry. Additionally, CD155 undergoes cell-matrix contacts by binding to the matrix protein vitronectin. Along with the receptor form, three soluble isoforms, α β, and γ, also exist in human serum and cerebrospinal fluid, and CD155 mRNAs are highly expressed in liver tissue. The presence of soluble CD155 reduces polivirus entry mediated by the membrane-bound receptor, implying an important role for these soluble forms in cellular function.

Specificity:

PVR polyclonal antibody detects endogenous levels of PVR protein.

Alternative names:

CD155; CD155 antigen; HVED; mE4; NECL 5; Necl-5; Necl5; Nectin like 5; Nectin like protein 5; Nectin-like protein 5; Ortholog of mouse Tage4; Poliovirus receptor; PVR; PVS; Taa1; Tage 4; TAGE4;

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human PVR.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 70 kDa

Applications:

WB IF

Usage:

WB 1:500 - 1:2000 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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