Bioworld Technology

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Catenin-α1 polyclonal antibody BS6976

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Specifications

size	50ul/100ul

Background:

α E-catenin (also designated α-catenin; cadherin-associated protein, alpha 1, 102kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via β- or γ-catenin and Actin. α E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. α E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, and is thus considered a contributing factor to metastasis.

Specificity:

Catenin-α1 polyclonal antibody detects endogenous levels of Catenin-α1 protein.

Alternative names:

Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13; CTNNA1; Catenin-α1; Catenin α1; αE-catenin; Catenin alpha-2; Alpha N-catenin; Alpha-catenin-related protein; CTNNA2; CAPR; Catenin-α2; Catenin α2; αN-catenin;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human Catenin-α1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 115kDa

Applications:

WB,IHC

Usage:

WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com