Background:

In the central nervous system GABA (γ-;aminobutyric acid) functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. ABAT (4-aminobutyrate aminotransferase), also known as GABAT (GABA aminotransferase), L-AIBAT or (S)-3-amino-2-methylpropionate transaminase, is a 500 amino acid mitochondrial matrix protein belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, which catabolizes GABA into succinic semialdehyde. Existing as a homodimer, ABAT binds pyridoxal phosphate as a cofactor and is expressed in liver, brain, pancreas, kidney, placenta and heart. The gene encoding ABAT maps to human chromosome 16p13.2, and defects in ABAT are the cause of GABA-AT deficiency, which is characterized by hypotonia, hyperreflexia, psychomotor retardation, lethargy, EEG abnormalities and refractory seizures.

Specificity:

ABAT polyclonal antibody detects endogenous levels of ABAT protein.

Alternative names:

(S) 3 amino 2 methylpropionate transaminase; (S)-3-amino-2-methylpropionate transaminase; 4 aminobutyrate aminotransferase; 4 aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate aminotransferase; ABAT; FLJ17813; FLJ30272; GABA aminotransferase; GABA AT; GABA T; GABA transaminase; GABA transferase; GABA-AT; GABA-T; GABAT; GABT_HUMAN; Gamma amino N butyrate transaminase; Gamma-amino-N-butyrate transaminase; hCG1984265; L AIBAT; L-AIBAT; LAIBAT; mitochondrial; NPD009;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human ABAT.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 49 kDa

Applications:

WB IHC IF

Usage:

WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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