Bioworld Technology

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OAS1 polyclonal antibody BS7726

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Specifications

size	50ul/100ul

Background:

The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility.

Specificity:

OAS1 polyclonal antibody detects endogenous levels of OAS1 protein.

Alternative names:

(2 5')oligo(A) synthetase 1; (2-5'')oligo(A) synthase 1; 2 5 Oligoadenylate Synthetase 1; 2 5' oligo A synthase 1; 2 5' oligo A synthetase 1; 2 5A synthase 1; 2 5A synthetase 1; 2' 5' oligo A synthetase 1; 2' 5' oligoadenylate synthetase 1 40/46kDa; 2' 5' oligoadenylate synthetase 1; 2' 5' oligoisoadenylate synthetase 1; 2''-5''-oligoadenylate synthase 1; 2'5' oligo A synthetase 1; 2'5' oligoadenylate synthetase 1; 2'5' oligoisoadenylate synthetase 1; 2-5A synthase 1; E18/E16; IFI 4; IFI4; OAS 1; OAS1; OAS1_HUMAN; OIAS; OIASI; p46/p42 OAS;

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human OAS1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 40 kDa

Applications:

WB IF

Usage:

WB 1:500 - 1:2000 IF 1:50 - 1:100

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com