Background:

Autotaxin (ATX), also designated ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2), is a membrane-bound glycoprotein that cleaves diester bonds for a broad range of substrates. Originally isolated from the human melanoma cell line (A2058), Autotaxin is predominantly expressed in brain, placenta, ovary and small intestine. Autotaxin has significant homology to the cell membrane differentiation antigen PC-1, and is a stimulator of tumor cell motility. It also functions as a catalyst by hydrollytically removing 5’-nucleotides from the 3’-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.

Specificity:

ENPP2 polyclonal antibody detects endogenous levels of ENPP2 protein.

Alternative names:

ATX; ATX X; ATX-X; Autotaxin; Autotaxin t; E NPP 2; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Enpp2; ENPP2_HUMAN; Extracellular lysophospholipase D; FLJ26803; LysoPLD; NPP2; PD IALPHA; PD-IALPHA; PDNP2; Phosphodiesterase I alpha; Phosphodiesterase I/nucleotide pyrophosphatase 2; Plasma lysophospholipase D;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human ENPP2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 110-115 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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