Background:

Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodesthe presinilin 1 (PSEN1) gene,which is one of the three key genes associated with the development of Alzheimer’s disease. The SERPINA1 gene islocated on chromosome 14 and when defective leadsto the genetic disorder α1-antitrypsin deficiency. This disorder is characterized bysevere lung complications and liver dysfunction. Notably, the immunoglobulin heavychain locusisfoundon chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein Bcl-3 in the translocationsfound in a variety of B cellmalignancies. The PSMC1 gene product has been provisionally designated PSMC1 pending furthercharacterization.

Specificity:

PSMC1 polyclonal antibody detects endogenous levels of PSMC1 protein.

Alternative names:

26S protease regulatory subunit 4; P26s4; 26S proteasome AAA-ATPase subunit RPT2; Proteasome 26S subunit ATPase 1; PSMC1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human PSMC1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 58 kDa

Applications:

WB,IHC

Usage:

WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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