Background:

RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The integrator complex is a multi-protein complex that associates with the C-terminal domain of Pol II and is involved in small nuclear RNAs (snRNA) U1 and U2 transcription, specifically in their 3’-box-dependent processing. A component of the integrator complex, INTS5 (integrator complex subunit 5), also known as KIAA1698, is a 1,019 amino acid multi-pass membrane protein localized to the nucleus. The gene encoding INTS5 maps to human chromosome 11q12.3 and mouse chromosome 19 A.

Specificity:

INTS5 polyclonal antibody detects endogenous levels of INTS5 protein.

Alternative names:

Integrator complex subunit 5; Int5; INTS5; KIAA1698

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human INTS5.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 120 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com