Background:

TXA synthase, also referred to as thromboxane synthase or CYP5, is an enzyme that catalyzes the conversion of the prostaglandin endoperoxide (PGH2) into Thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. TXA synthase is an important part of the cytochrome P450 system. Thromboxane A2 plays a pivotal role in the maintenance of hemostasis and cardiovascular diseases along with Prostacyclin. The expression of TXA synthase has been found to be consistently upregulated in several types of cancer tissues suggesting the involvement of this enzyme in tumor growth in humans. Thromboxanes are produced by TXA synthase in excess in inflammatory bowel disease.

Specificity:

TXA synthase polyclonal antibody detects endogenous levels of TXA synthase protein.

Alternative names:

BDPLT14; CYP5; CYP5A1; Cytochrome P450 5A1; Cytochrome P450; family 5; subfamily A; polypeptide 1; FLJ52771; GHOSAL; Platelet cytochrome P450 subfamily V; TBXAS1; THAS; THAS_HUMAN; Thromboxane A synthase 1 (platelet); Thromboxane A synthase 1 (platelet; cytochrome P450; family 5; subfamily A); Thromboxane A synthase 1; Thromboxane A synthase 1 platelet cytochrome P450 subfamily V; Thromboxane-A synthase; TS; TXA synthase; TXAS; TXS;

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human TXA synthase.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 50-56 kDa

Applications:

WB IHC IF

Usage:

WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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