Background:

The gene encoding murine TSLP maps to chromosome 18. Its human homologue is expressed in several tissues, including heart, liver and prostate. TSLP mediates its function by binding to a receptor complex: first binding with low affinity to a TSLP-specific chain designated TSLPR, (also designated CRLF2, cytokine receptor-like factor 2), then forming a high affinity complex with the IL-7Ra subunit, which explains the overlapping biological properties between TSLP and IL-7. Both TSLP and IL-7 induce phosphorylation of the transcription factor Stat5, but unlike IL-7, TSLP-mediated signaling does not activate the JAKs. TSLP prevents apoptosis and stimulates the proliferation of myeloid cells, which is supported by the coexpression of TSLPR and IL-7Ra on monocytes and dendritic cells.

Specificity:

CRLF2 polyclonal antibody detects endogenous levels of CRLF2 protein.

Alternative names:

CRL2; ILXR; TSLPR; TSLP receptor; Cytokine receptor-like 2; IL-XR

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human CRLF2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 50 kDa

Applications:

WB

Usage:

WB 1:200 - 1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com