Background:

The MAGUK family includes several mammalian proteins, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3), and the caspase-associated recruitment domain (CARD) proteins, all of which are related to the Drosophila tumor suppressor discs-large (dlg) gene product. CARD 8, also designated DACAR, NDPP1, TUCAN or CARDINAL, is a 431 amino acid protein that is expressed in the lung, ovary, testis, and placenta. It regulates cellular responses controlled by NF-˚ B activation and may play a key role in apoptosis and chronic inflammatory disorders. CARD 8 binds to caspase-1 and negatively regulates its activity.

Specificity:

CARD8 polyclonal antibody detects endogenous levels of CARD8 protein.

Alternative names:

Apoptotic protein NDPP 1; Apoptotic protein NDPP1; CARD 8; CARD inhibitor of NF kappa B activating ligand; CARD inhibitor of NF kappaB activating ligand; CARD inhibitor of NF kappaB activating ligands; CARD-inhibitor of NF-kappa-B-activating ligand; CARD8; CARD8; CARDINAL; Caspase recruitment domain containing protein 8; Caspase recruitment domain family member 8; Caspase recruitment domain protein 8; Caspase recruitment domain-containing protein 8; DACAR; DKFZp779L0366; KI

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human CARD8.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 60 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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