Background:

GALT (galactose-1-phosphate uridylyltransferase) is a 379 amino acid member of the galactose-1-phosphate uridylyltransferase type 1 family of proteins. GALT exists as a homodimer and is believed to play a role in galactose metabolism. More specifically, GALT is responsible for catalyzing the reaction of UDP-glucose with α-D-galactose 1-phosphate to produce α-D-glucose 1-phosphate and UDP-galactose. This is the second step of the Leloir pathway of galactose metabolism. The products of this reaction will either enter the glycolytic pathway to yield energy (α-D-glucose 1-phosphate) or be used as a galactosyl donor in the synthesis of glycoproteins and glycolipids (UDP-galactose). Mutations in the gene encoding GALT can lead to galactosemia, a disorder (occurring from the inability to metabolize galactose) that is characterized by cataracts, mental retardation and jaundice. In newborns, galactosemia can be fatal if lactose is not removed from the diet.

Specificity:

GALT polyclonal antibody detects endogenous levels of GALT protein.

Alternative names:

Galactose-1-phosphate uridylyltransferase; Gal-1-P uridylyltransferase; UDP-glucose--hexose-1-phosphate uridylyltransferase; GALT

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human GALT.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

Refer to Figures

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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