Background:

The Saccharomyces cerevisiae protein, PMR1, encodes P-type calcium transport ATPase, which localizes to the Golgi and regulates the intracellular transport of calcium and manganese. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). PMR1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. PMR1 is mutated in Hailey-Hailey disease (HHD), which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.

Specificity:

ATP2C1 polyclonal antibody detects endogenous levels of ATP2C1 protein.

Alternative names:

ATP dependent Ca(2+) pump PMR1; ATP-dependent Ca(2+) pump PMR1; ATP2C1; ATP2C1A; ATPase 2C1; ATPase Ca(2+) sequestering; ATPase Ca++ transporting type 2C member 1; AW061228; BCPM; Calcium transporting ATPase type 2C member 1; Calcium-transporting ATPase type 2C member 1; D930003G21Rik; HHD; hSPCA1; HUSSY 28; KIAA1347; PMR1; PMR1, rat, homolog of; PMR1L; Secretory pathway Ca(2+) ATPase 1; Secretory pathway Ca(2+)-transporting ATPase; Secretory pathway Ca2+/Mn2+ ATPase 1; SPCA; SPCA1;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human ATP2C1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 125 kDa

Applications:

WB IHC IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

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