Background:

The small ubiquitin-related modifier protein SUMO-1 belongs to the ubiquitin-like protein family, which are synthesized as precursor proteins that undergo processing before conjugation to target proteins. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processes, including nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO-1 utilizes homologues of the E1 and E2 enzymes for conjugation to proteins, which include IkBα, MDM2, p53, PML, and RanGap1. AOS1 is homologous to the N-terminal half of E1 and UBA2 is homologous to the C-terminal half of E1. These proteins form a heterodimer that activates SUMO-1.

Specificity:

SAE2/UBA2 polyclonal antibody detects endogenous levels of SAE2/UBA2 protein.

Alternative names:

UBA2, SAE2, UBLE1B, HRIHFB2115, Anthracycline associated resistance ARX, Anthracycline-associated resistance ARX, ARX, FLJ13058, HRIHFB2115, SAE 2, SAE2, SAE2, SUMO 1 activating enzyme subunit 2, SUMO activating enzyme subunit 2, SUMO-activating enzyme subunit 2, UBA2, UBA2 ubiquitin activating enzyme E1 homolog, Ubiquitin like 1 activating enzyme E1B, Ubiquitin like modifier activating enzyme 2, Ubiquitin-like 1-activating enzyme E1B, UBLE1B,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

~ 80 kDa

Applications:

WB IP

Usage:

WB: 1:500 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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