Background:

ACSS2 (acyl-CoA synthetase short-chain family member 2), also known as ACAS2, ACS, ACSA or AceCS, is a 701 amino acid cytoplasmic protein that belongs to the ATP-dependent AMP-binding enzyme family. Existing as a monomer, ACSS2 functions to catalyze the ATP-dependent activation of acetate, a reaction that yields acetyl-CoA for use in energy generation and lipid synthesis. ACSS2 expression, which is highest in liver and kidney tissue, is regulated by the presence of unsaturated fatty acids and sterol regulatory element-binding proteins (SREBPs). Human ACSS2 exists as two alternatively spliced isoforms and shares 93% sequence identity with its mouse counterpart, suggesting a conserved role between species.

Specificity:

ACS polyclonal antibody detects endogenous levels of ACS protein.

Alternative names:

ACS, AceCS, ACSS2, ACAS2, AceCS, Acetate CoA ligase, Acetate thiokinase, AcetateCoA ligase, Acetyl CoA synthetase, Acetyl Coenzyme A synthetase 2 (ADP forming), Acetyl coenzyme A synthetase cytoplasmic, Acetyl-CoA synthetase, Acetyl-coenzyme A synthetase, ACS, ACSA, ACSA, ACSS2, Acyl activating enzyme, Acyl CoA synthetase short chain family member 2, Acyl-activating enzyme, Acyl-CoA synthetase short-chain family member 2, Cytoplasmic acetyl coenzyme A synthetase, cytoplasmic, MYH7B,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

~ 79 kDa

Applications:

WB ICC/IF

Usage:

WB:1:1,000 ICC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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