Background:

Heterogeneous nuclear ribonucleoprotein U-like protein 2, is a multifunctional protein and previous studies have implicated it in the modulation of p53 transcriptional activity, although this has been rather poorly understood. Results presented here demonstrate that hnRNPUL-1 represses p53 transcriptional activity and negatively regulates p21 levels. This is consistent with the depletion of hnRNPUL-1 leading to an increase in cells arrested in G1/S. Together these results confirm that hnRNPUL-1 acts as a p53 co-repressor with specific cellular targets.

Specificity:

hnRNP UL2 polyclonal antibody detects endogenous levels of hnRNP UL2 protein.

Alternative names:

Heterogeneous nuclear ribonucleoprotein U-like protein 2; Scaffold-attachment factor A2; SAF-A2; HNRNPUL2; HNRPUL2

Species reactivity:

Human,Rat,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Immunogen:

Synthetic peptide, corresponding to Human hnRNP UL2.

Purification & Purity:

The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 90 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com