Background:

Gas8 (growth arrest-specific 8), also known as Gas11, is a 478 amino acid protein that localizes to the Golgi apparatus, as well as to the cytoplasm and the flagellar basal body, and belongs to the growth arrest-specific protein family. Expressed in liver, heart and skeletal muscle with lower levels present in lung, brain, kidney and placenta, Gas8 functions as a cytoskeletal linker that binds microtubules and is thought to play a role in axonemal and non-axonemal dynein regulation. Gas8 may also be involved in spermatozoa motility and, when defective, may be associated with infertility in males lacking gametocytes. The gene encoding Gas8 maps to a region on human chromosome 16 that is frequently deleted in breast and prostate cancer, suggesting a role for Gas8 in tumorigenesis.

Specificity:

GAS8 polyclonal antibody detects endogenous levels of GAS8 protein.

Alternative names:

Dynein regulatory complex subunit 4; Growth arrest-specific protein 11; GAS-11; Growth arrest-specific protein 8; GAS-8; GAS8; DRC4;GAS11

Species reactivity:

Human,Rat,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Immunogen:

Synthetic peptide, corresponding to Human GAS8.

Purification & Purity:

The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 56 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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