Background:

GITRL (glucocorticoid-induced TNF-related ligand), a polypeptide encoded by a human umbilical endothelial cell cDNA, is a member of the TNF (tumor necrosis factor) superfamily. GITRL has a type 2 transmembrane topology that is characteristic of the TNF family. The TNF superfamilies regulate diverse biological functions, including cell proliferation, differentiation and survival. GITRL is found on vascular endothelial cells and in several peripheral tissues (small intestine, ovary, testis and kidney), where it may modulate T lymphocyte survival. The GITR receptor recognizes GITRL and the two interact to regulate NFκB activation. The ligand-receptor pair of GITRL-GITR protects cells against AICD (activation-induced cell death).

Specificity:

GITRL polyclonal antibody detects endogenous levels of GITRL protein.

Alternative names:

Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to Human GITRL.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 20 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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