Background:

Zinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellular functions (such as neuroregulation) and acts as a cofactor for numerous enzymes and transcription factors. The zinc transporter (ZnT) family regulates the supply of zinc within cells, and its members commonly contain six membrane-spanning domains, a large histidine-rich intracellular loop and a C-terminal tail. ZnT-8 (zinc transporter 8), also known as SLC30A8 (solute carrier family 30 member 8), is a 369 amino acid multi-pass membrane protein that belongs to the ZnT family and is a major autoantigen in type I diabetes. Expressed specifically in pancreas islet cells, ZnT-8 functions as a zinc-efflux transporter that facilitates the accumulation of zinc in intracellular vesicles and is essential for the zinc-dependent maturation of Insulin within pancreatic cells. Multiple isoforms of ZnT-8 exist due to alternative splicing events.

Specificity:

ZNT8 polyclonal antibody detects endogenous levels of ZNT8 protein.

Alternative names:

Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8; SLC30A8; ZNT8

Species reactivity:

Human,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to Human ZNT8.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 41 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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