Background:

Ubiquitin (Ub) is among the most phylogenetically conserved proteins known. The primary function of this small, 76 amino acid protein is to clear abnormal, foreign and improperly folded proteins by targeting them for degradation by the 26S proteosome. Many ubiquitin-like proteins function as post-translational protein modifiers, such as members of the SUMO protein family, however some ubiquitin-like proteins regulate protein-protein interactions and cell cycle events, thereby functioning outside of the traditional ubiquitination pathway. UBQLN3 (Ubiquilin-3) is a 654 amino acid protein containing one N-terminal ubiquitin-like (UBQ) domain and one C-terminal UBA domain. With expression limited to testis, it has been suggested that UBQLN3 may associate with testis-specific cyclin A1 and/or cyclin A to regulate the cell cycle during spermatogenesis. Similarly, a family member related to UBQLN3, namely PLIC-1, also known as Ubiquilin-1, may also play a critical role in cell cycle regulation.

Specificity:

Ubiquilin 3 polyclonal antibody detects endogenous levels of Ubiquilin 3 protein.

Alternative names:

Ubiquilin-3; UBQLN3

Species reactivity:

Human,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to Human Ubiquilin 3.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 71 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com