Background:

Members of the CLASP family, including CLASP1, are mammalian microtubule plus-end binding proteins that interact with CLIPs in order to stabilize the microtubule structures in transfected cells. CLASP1 localizes near the distal end of growing spindle microtubules during mitosis and is a component of the outer corona region of kinetochores. CLASP proteins stabilize microtubules by promoting pauses and restricting MT growth. Defects in CLASP1 cause collapse of the spindle, attachment of kinetochores to short microtubules, and other abnormal mitotic behaviors.

Specificity:

CLASP1 polyclonal antibody detects endogenous levels of CLASP1 protein.

Alternative names:

CLIP-associating protein 1; Cytoplasmic linker-associated protein 1; Multiple asters homolog 1; Protein Orbit homolog 1; hOrbit1; CLASP1; KIAA0622, MAST1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to Human CLASP1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 169 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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