Background:

Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-L41 (mitochondrial ribosomal protein L41), also known as cell proliferation-inducing gene 3 protein and BMRP (Bcl-2-interacting mitochondrial ribosomal protein L41), is a 137 amino acid protein that localizes to the mitochondrion, where it exists as a component of the 39S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis. Expressed in liver, testis, kidney and thymus, MRP-L41 is in-volved in the cell cycle and apoptosis. Possibly by stabilizing p21 and p27, MRP-L41 has the ability to arrest the cell cycle in the G1 phase. MRP-L41 also enhances p53 stability, therefore contributing to p53-induced apoptosis in response to growth-inhibitory conditions

Specificity:

MRPL41 polyclonal antibody detects endogenous levels of MRPL41 protein.

Alternative names:

39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41; 39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homolog; Mitochondrial large ribosomal subunit protein mL41; MRPL41; BMRP; MRPL27; RPML27; PIG3

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to Human MRPL41.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 15 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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