Background:

FARSLB (Phenylalanine--tRNA ligase beta chain), also known as FARSB, FRSB, PheHB or PheRS, is a 589 amino acid cytoplasmic protein that is the regulatory beta subunit of phenylalanine-tRNA synthetase. A highly conserved member of the aminoacyl-tRNA synthetase class IIc subfamily, FARSLB functions to enzymatically attach L-phenylalanine residues to terminal adenosines on tRNA(Phe). This is an ATP-dependent reaction that yields AMP, a diphosphate and an L-phenylalanine-tagged tRNA(Phe). FARSLB is expressed in brain, heart, kidney, pancreas, placenta and skeletal muscle and its expression is increased in malignant cell lines, suggesting a possible role for FARSLB in carcinogenesis.

Specificity:

FARSLB polyclonal antibody detects endogenous levels of FARSLB protein.

Alternative names:

Phenylalanine--tRNA ligase beta subunit; Phenylalanyl-tRNA synthetase beta subunit; PheRS; FARSB; FARSLB; FRSB; HSPC173

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human FARSLB.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 80 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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