Background:

A member of the serine / threonine protein kinase family, PTEN induced putative kinase 1 (PINK1) is a tumor suppressor. PINK1 is primarily located in mitochondria, and is ubiquitously expressed in testis, skeletal muscle, and heart tissue. at lower levels in pancreas, ovary, brain, placenta, kidney, liver, prostate and small intestine. During cellular stress PINK1 protects against mitochondrial dysfunction by inducing phosphorylation mitochondrial proteins. PINK1 mutations may give rise to different autophosphorylation activity. Mutations in the PINK1 gene (PARK6) are associated with early onset Parkinson's disease, a recessive neurodegenerative disorder characterized by resting tremor, muscular rigidity, bradykinesia and postural instability. Parkinson's disease generally involves the presence of intraneuronal accumulations of aggregated proteins (Lewy bodies) in brain neurons.

Specificity:

PINK1 polyclonal antibody detects endogenous levels of PINK1 protein.

Alternative names:

PINK1, BRPK, FLJ27236, mitochondrial, PARK 6, PARK6, Phosphatase and Tensin Homolog, PINK 1, PINK1, PINK1, Protein kinase BRPK, PTEN induced putative kinase 1, PTEN induced putative kinase protein 1, PTEN-induced putative kinase protein 1, Serine/threonine kinase PINK1 mitochondrial, Serine/threonine protein kinase PINK1 mitochondrial, Serine/threonine-protein kinase PINK1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

Protein affinity purified

Molecular weight:

~ 60kDa

Applications:

WB IHC

Usage:

WB:1:1000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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