Background:

Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotin-amide and other pyridines. NNMT activity in the human liver has a bimodal frequency distribution, indicating that its enzyme activity may be modulated through a genetic polymorphism, which could have functional implications for individual differences in drug and xenobiotic toxicity. The gene that encodes human NNMT is approximately 16.5 kb in length, consists of three exons and two introns and maps to 11q23.2. NNMT isolated from the human liver was determined to be 969 nucleotides in length, with a 792 nucleotide open reading frame that encodes a 264 amino acid protein. The NNMT gene is presumed to be a significant genetic determinant of plasma homocysteine levels in Spanish families, since it encodes an enzyme involved in homocysteine synthesis.

Specificity:

NNMT polyclonal antibody detects endogenous levels of NNMT protein.

Alternative names:

Nicotinamide N-methyltransferase; NNMT

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human NNMT.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 29 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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