Background:

Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is upregulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. ACPT dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage. ACPT is predominantly expressed in testis but exhibits a lower level of expression in testicular cancer tissues than in normal tissues. ACPT has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Specificity:

ACPT Polyclonal Antibody detects endogenous levels of ACPT protein.

Alternative names:

Acid phosphatase testicular; Testicular acid phosphatase; PPAT_HUMAN.

Species reactivity:

Human,Mouse,Rat,Dog,Horse,

Host:

Rabbit

Ig type:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Immunogen:

KLH conjugated synthetic peptide derived from human ACPT:65-160/437

Purification & Purity:

affinity purified by Protein A

Molecular weight:

47kDa

Applications:

FCM,

Usage:

Flow-Cyt=0.2ug/test

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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