Background:

Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. IκBinteracting Ras-like proteins, κB-Ras1 and κB-Ras2, belong to a subclass of evolutionarily conserved Ras-like proteins that differ from other Ras proteins in containing amino acids at positions 12 and 61 that are similar to those present in the oncogenic forms of Ras. These Ras-like proteins, κB-Ras1 and κB-Ras2, interact with the PEST domains of IκBa and IκBb and decrease their rate of degradation. κB-Ras2 shows 71% identity to κB-Ras1. In cells,κB-Ras proteins are associated only with NFκB:IκBb complexes and therefore may provide an explanation for the slower rate of degradation of IκBb compared with IκBa.

Specificity:

NKIRAS1 polyclonal Antibody detects endogenous levels of NKIRAS1 protein.

Alternative names:

2400004O09Rik; I kappa B interacting Ras like protein 1; I-kappa-B-interacting Ras-like protein 1; Kappa B Ras 1; Kappa B Ras protein 1; Kappa B-Ras protein 1; KappaB Ras1; KappaB-Ras1; KBRAS 1; KBRAS1; KBRS1_HUMAN; NF kappa B inhibitor interacting Ras like protein 1; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras like 1; NFKB inhibitor interacting Ras like protein 1; NKIRAS 1; nkiras1.

Species reactivity:

Human,Mouse,Rat,Dog,Pig,Horse,Rabbit,

Host:

Rabbit

Ig type:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Immunogen:

KLH conjugated synthetic peptide derived from human NKIRAS1:131-192/192

Purification & Purity:

affinity purified by Protein A

Molecular weight:

~22kDa

Applications:

WB,

Usage:

WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com