Background:

TBRG4 (transforming growth factor b regulator 4), also known as CPR2 (cell cycle progression restoration protein 2) or FASTKD4 (FAST kinase domaincontaining protein 4), is a 631 amino acid protein that contains one RAP domain and belongs to the FAST kinase family. TBRG4 is ubiquitously expressed and may have a role in cell cycle progression. Existing as two alternatively spliced isoforms, the gene encoding TBRG4 maps to human chromosome 7p13. Chromosome 7 is approximately 158 million bases long, encodes over 1,000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.

Specificity:

TBRG4 polyclonal antibody detects endogenous levels of TBRG4 protein.

Alternative names:

TBRG4;CPR2;FASTKD4

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Immunogen:

Recombinant fusion protein containing a sequence corresponding to amino acids 382-631 of human TBRG4 (NP_004740.2).

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 80 kDa

Applications:

WB IF

Usage:

WB: 1:500 - 1:2000 IF: 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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