Background:

Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2. TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs). TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation. TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation. High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2. Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis.

Specificity:

TR4 polyclonal antibody detects endogenous levels of TR4 protein.

Alternative names:

Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4; NR2C2; TAK1, TR4

Species reactivity:

Human,Pig

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Immunogen:

Synthetic peptide, corresponding to Human TR4.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 67 kDa

Applications:

WB

Usage:

WB: 1:2000~1:5000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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