Background:

Intelectin-1, also known as ITLN1, INTL, Omentin or LFR, is a 313 amino acid protein that contains one fibrinogen C-terminal domain and is either secreted or lipid-anchored to the cell membrane. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, Intelectin-1 exists as a disulfide-linked homotrimer that functions to enhance Insulin-stimulated glucose uptake and is also thought to participate in host defense against miccroorganisms. In addition to its roles in glucose regulation and immune system function, Intelectin-1 may also be involved in iron metabolism and obesity regulation in adults. Intelectin-2 shares 85% amino acid identity with Intelectin-1 and, like Intelectin-1, is a secreted protein that contains one fibrinogen C-terminal domain and is thought to play a role in the host defense system. While Intelectin-1 is present in a variety of tissues, Intelectin-2 exists only in the small intestine.

Specificity:

LFR polyclonal antibody detects endogenous levels of LFR protein.

Alternative names:

Intelectin-1; ITLN-1; Endothelial lectin HL-1; Galactofuranose-binding lectin; Intestinal lactoferrin receptor; Omentin

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to Human LFR.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 34 kDa

Applications:

WB IHC

Usage:

WB: 1:1000~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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