Background:

The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene.

Specificity:

HSD3B polyclonal antibody detects endogenous levels of HSD3B protein.

Alternative names:

3 beta and steroid delta isomerase 1; 3 beta and steroid hydroxy delta 5 steroid dehydrogenase; 3 beta HSD I; 3BH; 3BHSD; HGNC:5217; HSD3B; HSD3B1; HSDB3; HSDB3A; Hydroxy delta 5 steroid dehydrogenase 3 beta and steroid delta isomerase 1; Hydroxy delta 5 steroid dehydrogenase; trophoblast antigen; 3BHS1_HUMAN; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; Short=3-beta-HSD I; Trophoblast antigen FDO161G; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta-5-3-ketosteroid isomerase

Species reactivity:

Mouse

Host:

Rabbit

Ig type:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Immunogen:

KLH conjugated synthetic peptide derived from human HSD3B1+ HSD3B2: 101-200/372

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 42 kDa

Applications:

WB ELISA

Usage:

WB: 1:500~1:2000 ELISA：1:5000-1:10000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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