Background:

Kinectin 1 (KTN1) is an endoplasmic reticulum (ER)-enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1). Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking. The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly. Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER. Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer, hepatocellular carcinoma (HCC), Parkinson's disease , and the autoimmune syndrome Behçet's disease (BD)

Specificity:

Recognizes endogenous levels of Kinectin 1 protein.

Alternative names:

CG1; KIAA0004; Kinectin; CG-1 antigen; Kinesin receptor

Species reactivity:

Human, Mouse

Host:

Rabbit

Ig type:

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Immunogen:

KLH-conjugated synthetic peptide of human Kinectin 1

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 160 kDa

Applications:

WB, IHC

Usage:

WB (1/500 - 1/2000), IHC (1/50 - 1/200)

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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Email: info@sobekbio.com

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