Arginase 1 monoclonal antibody MB66233
Specifications
| 50ul/100ul |
Background:
L-arginine plays a critical role in regulating the immune system (1-3). In inflammation, cancer and certain other pathological conditions, myeloid cell differentiation is inhibited leading to a heterogeneous population of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs). MDSCs are recruited to sites of cancer-associated inflammation and express high levels of arginase-1 . Arginase-1 catalyzes the final step of the urea cycle converting L-arginine to L-ornithine and urea . Thus MDSCs increase the catabolism of L-arginine resulting in L-arginine depletion in the inflammatory microenvironment of cancer (4,6). The reduced availability of L-arginine suppresses T-cell proliferation and function and thus contributes to tumor progression (4,6). Arginase-1 is of great interest to researchers looking for a therapeutic target to inhibit the function of MDSCs in the context of cancer immunotherapy . In addition, research studies have demonstrated that Arginase-1 distinguishes primary hepatocellular carcinoma (HCC) from metastatic tumors in the liver, indicating its value as a potential biomarker in the diagnosis of HCC
Specificity:
Recognizes endogenous levels of Arginase 1 protein.
Alternative names:
Arginase-1; Liver-type arginase; Type I arginase
Species reactivity:
Human
Host:
Mouse
Ig type:
Mouse IgG2a. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Immunogen:
KLH-conjugated synthetic peptide encompassing a sequence within human Arginase 1. The exact sequence is proprietary.
Purification & Purity:
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Molecular weight:
~ 34 kDa
Applications:
IHC
Usage:
IHC (1/100 - 1/300)
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Precautions:
For research use only, not for use in diagnostic procedure.
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com