Background:

Wilms' Tumor 1 (WT1) is a transcription factor named from Wilms' Tumor 1, an embryonal malignancy of the kidneys that is caused by mutations in the WT1 gene . It is highly important in development, particularly of the genitourinary system, and mutations and dysregulation of expression of WT1 result in a variety of syndromes affecting the genitourinal system and other tissues. WT1 has a myriad of biological functions and a host of interacting partners and target genes . It can behave as a transcriptional activator, or a repressor, and can act as an oncogene or a tumor suppressor . It exerts influence over the epigenetic landscape, and also has post translational influence of gene expression through RNA interactions . The diverse biological roles of WT1 have been attributed to the existence of multiple isoforms and post translation modifications of the protein.

Specificity:

Recognizes endogenous levels of Wilms Tumor 1 protein.

Alternative names:

Wilms tumor protein; WT33

Species reactivity:

Human

Host:

Mouse

Ig type:

Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Immunogen:

KLH-conjugated synthetic peptide encompassing a sequence within human Wilms Tumor 1. The exact sequence is proprietary.

Purification & Purity:

The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 49 kDa

Applications:

IHC

Usage:

IHC (1/100 - 1/300)

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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