Background:

Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9.

Specificity:

Recognizes human HLA-A/B/C

Alternative names:

HLA-A; HLAA; HLA class I histocompatibility antigen, A-68 alpha chain; Aw-68; HLA class I histocompatibility antigen, A-28 alpha chain; MHC class I antigen A*68; HLA-A; HLAA; HLA class I histocompatibility antigen, A-2 alpha chain; MHC class I antigen A*2; HLA-A; HLAA; HLA class I histocompatibility antigen, A-3 alpha chain; MHC class I antigen A*3; HLA-A; HLAA; HLA class I histocompatibility antigen, A-24 alpha chain; Aw-24; HLA class I histocompatibility antigen, A-9 alpha chain; MHC class I antigen A*24; HLA-A; HLAA; HLA class I histocompatibility antigen, A-32 alpha chain; MHC class I antigen A*32; HLA-A; HLAA; HLA class I histocompatibility antigen, A-69 alpha chain; Aw-69; HLA class I histocompatibility antigen, A-28 alpha chain; MHC class I antigen A*69; HLA-A; HLAA; HLA class I histocompatibility antigen, A-11 alpha chain; MHC class I antigen A*11; HLA-A; HLAA; HLA class I histocompatibility antigen, A-31 alpha chain; MHC class I antigen A*31; HLA-A; HLAA; HLA class I histocompatibility antigen, A-25 alpha chain; HLA class I histocompatibility antigen, A-10 alpha chain; MHC class I antigen A*25; HLA-A; HLAA; HLA class I histocompatibility antigen, A-1 alpha chain; MHC class I antigen A*1; HLA-A; HLAA; HLA class I histocompatibility antigen, A-26 alpha chain; MHC class I antigen A*26; HLA-A; HLAA; HLA class I histocompatibility antigen, A-34 alpha chain; Aw-34; HLA class I histocompatibility antigen, A-10 alpha chain; MHC class I antigen A*34; HLA-A; HLAA; HLA class I histocompatibility antigen, A-36 alpha chain; Aw-36; MHC class I antigen A*36

Species reactivity:

Human

Host:

Mouse

Ig type:

Mouse IgG2a kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Immunogen:

Purification & Purity:

The monoclonal antibody was affinity-purified from Mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 40 kDa

Applications:

IF, FC

Usage:

IF (1/50 - 1/200)

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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