Background:

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes . COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation . COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.

Specificity:

COUP-TF II polyclonal antibody detects endogenous levels of COUP-TF II protein.

Alternative names:

COUP transcription factor 2; Apolipoprotein A-I regulatory protein 1; COUP transcription factor II; COUP-TF2; Nuclear receptor subfamily 2 group F member 2; ARP-1; COUP-TF II; NR2F2; ARP1; TFCOUP2

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Immunogen:

Synthetic peptide, corresponding to Human COUP-TF II.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 47 kDa

Applications:

WB IHC

Usage:

WB: 1:1000~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com