Background:

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis.Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2.In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation.

Specificity:

BMP-5 (L163) polyclonal antibody detects endogenous levels of BMP-5 protein.

Alternative names:

Bone morphogenetic protein 5; BMP-5

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Immunogen:

Synthetic peptide, corresponding to Human BMP-5.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 53 kDa

Applications:

WB

Usage:

WB: 1:2000~1:5000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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