Background:

The ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in a wide range of mammalian tissues and several are abundantly expressed in the male reproductive tract. ADAM22 and ADAM23 (designated MDC2 and MDC3, respectively) are structurally similar proteins that contain a disrupted zinc-binding motif, and both are highly expressed in brain (4-6). The genes encoding human ADAM22 and ADAM23 map to chromosomes 7q21 and 2q33, respectively.

Specificity:

ADAM22 polyclonal antibody detects endogenous levels of ADAM22 protein.

Alternative names:

MDC2

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human ADAM22.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 100 kDa

Applications:

WB

Usage:

WB 1:1000 - 1:4000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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