Background:

GABARAPL1 (γ-aminobutyric acid receptor-associated protein-like 1), also known as ATG8, GEC1 (glandular epithelial cell protein 1), APG8L, ATG8L or APG8-LIKE, is a 117 amino acid protein belonging to the MAP1 LC3 family. Localized to the endoplasmic reticulum and Golgi apparatus, GABARAPL1 is ubiquitously expressed. Very high levels of GABARAPL1 are found in brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. GABARAPL1 increases cell-surface expression of κ-type opioid receptor (KOR) through facilitating anterograde intracellular trafficking of the receptor. GABARAPL1 may have chaperone-like effects for many cell surface proteins along the biosynthesis pathway and may regulate the trafficking of receptor GABA. GABARAPL1 interacts with GABAA Rγ2, β Tubulin and KOR-1.

Specificity:

GABARAPL1 polyclonal antibody detects endogenous levels of GABARAPL1 protein.

Alternative names:

ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human GABARAPL1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 14 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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