Background:

PHB2 (Prohibitin 2) is a Protein Coding gene. Diseases associated with PHB2 include marinesco-sjogren syndrome and urethritis. Among its related pathways are Akt Signaling Pathway and GPCR Pathway. GO annotations related to this gene include estrogen receptor binding. Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Specificity:

PHB2 polyclonal antibody detects endogenous levels of PHB2 protein.

Alternative names:

BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141; D-prohibitin; Prohibitin-2; Prohibitin 2; Prohibitin2;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human PHB2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 33 kDa

Applications:

WB,IHC,IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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